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When DNA is coiled up into chromatin, it’s inaccessible to transcription, and genes are therefore silent. When it’s uncoiled, genes are active. This process, normally controlled by methyl groups, is called epigenetics. Chroma Medicine designs programmable epigenetic editors with effector domains that create precise, durable methylation patterns — thus activating, silencing, or tuning expression of targeted genes, in a way that’s safer and more predictable than alternative gene editing approaches that cut or alter DNA sequences.
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Avicenna Biosciences
Using AI to speed through the last mile of drug discovery
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Latus Bio
Finding precisely tuned viral vectors for gene therapy in CNS disorders
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Radionetics Oncology
Discovering more precise ways to deploy radiopharmaceuticals against solid tumors
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DVLP Medicines
Creating a software co-pilot for drug development and a new marketplace for investors and outsourced R&D and manufacturing