Chroma Medicine

When DNA is coiled up into chromatin, it’s inac­ces­sible to tran­scrip­tion, and genes are therefore silent. When it’s uncoiled, genes are active. This process, normally controlled by methyl groups, is called epigenetics. Chroma Medicine designs program­mable epigenetic editors with effector domains that create precise, durable methylation patterns — thus activating, silencing, or tuning expression of targeted genes, in a way that’s safer and more predictable than alternative gene editing approaches that cut or alter DNA sequences.